A dual agonist of FXR and PPARδ
货号:ajcx24020
CAS:2522599-79-5
分子式:C28H25Cl3N2O4
分子量：559.9
溶解度:Acetonitrile: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：
现货Background:
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 µM.
1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)
