An internal standard for the quantification of vildagliptin
货号:ajcx23730
CAS:1133208-42-0
分子式:C17H18D7N3O2
分子量：310.4
溶解度:DMF: 20 mg/ml,DMSO: 15 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Vildagliptin-d₇has 7 deuteriums. Vildagliptin-d₇is intended for use as an internal standard for the quantification of vildagliptin by GC- or LC-MS. Vildagliptin is an inhibitor of DPP-4 (IC₅₀= 3.5-34 nM).^1,2It also inhibits DPP-8 and DPP-9 (K_i= 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α.³Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.^4,5Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.^6,7

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