An antibiotic complex
货号:ajcx23392
CAS:76168-82-6
分子式:C119H154ClN21O40 (for A2)
分子量：2554.1
溶解度:DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ramoplanin complex is a mixture of ramoplanin A1, -A2, and -A3 originally isolated fromActinoplanesthat has antibacterial activity.^1,2,3Ramoplanin complex is active against clinical isolates of the Gram-positive bacteriaS. aureus,S. pyogenes,S. pneumoniae, andS. faecalis(MICs = 0.016-2 µg/ml) but not Gram-negative bacteria orC. albicans(MICs = ≥128 µg/ml).²It inhibits cell wall synthesis inB. subtiliswhen used at a concentration of 0.5 µg/ml.¹Ramoplanin complex is effective against systemicS. pyogenes,S. pneumoniae, andS. aureusinfections in mice with ED₅₀values of 0.081, 0.14, and approximately 25 mg/kg per day, respectively.

1.Cavalleri, B., Pagani, H., Volpe, G., et al.A-16686, a new antibiotic from actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristicsJ. Antibiot. (Tokyo)37(4)309-317(1984) 2.Pallanza, R., Berti, M., Scotti, R., et al.A-16686, a new antibiotic from actinoplanes. II. Biological propertiesJ. Antibiot. (Tokyo)37(4)318-324(1984) 3.Shin, D., Rew, Y., and Boger, D.L.Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complexProc. Natl. Acad. Sci. USA101(33)11977-11979(2004)