An inhibitor of MAGL
货号:ajcx22034
CAS:2514-37-6
分子式:C15H13NOS
分子量：255.3
溶解度:DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC₅₀= 34.1 nM).¹It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 µM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(3)1261-1280(2020)