A STING inhibitor
货号:ajcx21896
CAS:2244881-69-2
分子式:C17H20N2O4
分子量：316.4
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C-171 is an inhibitor of stimulator of interferon genes (STING).[1],[2] It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.[1] It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM.

参考文献:
[1].Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018)
[2].Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019)