An inactive control for DO264
货号:ajcx20962
CAS:2301865-01-8
分子式:C23H20Cl2F3N5O2S
分子量：558.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(S)-DO271 is an inactive control for the α/β-hydrolase domain-containing protein 12 (ABHD12) inhibitor DO264 .^1,2Unlike DO264, (S)-DO271 does not inhibit ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates when used at a concentration of 1 µM or modify inflammatory cytokine production in M1-polarized THP-1 macrophages.

1.Ogasawara, D., Ichu, T.-A., Vartabedian, V.F., et al.Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivoNat. Chem. Biol.14(12)1099-1108(2018) 2.Ogasawara, D., Ichu, T.-A., Jing, H., et al.Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)J. Med. Chem.62(3)1643-1656(2019)