A competitive STING ligand
货号:ajcx20772
CAS:N/A
分子式:C29H27ClFNO5
分子量：524
溶解度:DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml,DMSO: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells.

|1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019).