An mtMGST1 inhibitor
货号:ajcx20640
CAS:24425-56-7
分子式:C16H29N3O6S
分子量：391.5
溶解度:DMSO: slightly soluble,DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hexylglutathione is a mitochondrial membrane-bound microsomal glutathione S-transferase 1 (mtMGST1) inhibitor (IC50 = 0.48 mM).1 It also inhibits the dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF; IC50 = 3.3 mM).2 It has been used as an affinity chromatography ligand to purify glutathione S-transferase (GST) from sheep liver homogenate.3

|1. Ulziikhishig, E., Lee, K.K., Hossain, Q.S., et al. Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A. Life Sci. 86(19-20), 726-732 (2010).|2. Swope, M.D., Sun, H.W., Klockow, B., et al. Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione. J. Biol. Chem. 273(24), 14877-14884 (1998).|3. Reddy, C.C., Burgess, Z.Z., Gong, Z.Z., et al. Purification and characterization of the individual glutathione S-transferases from sheep liver. Arch. Biochem. Biophys. 224(1), 87-101 (1983).