Milrinone-d3 is intended for use as an internal standard for the quantification of milrinone by GC- or LC-MS.
货号:ajcx17538
CAS:N/A
分子式:C12H6D3N3O
分子量：214.2
溶解度:DMF: 0.3 mg/ml,DMSO: 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Milrinone-d3 is intended for use as an internal standard for the quantification of milrinone by GC- or LC-MS. Milrinone is an inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1 μM, respectively. It is selective for PDE3 over PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 263, >300, 17.5, 49.1, and 58.3 μM, respectively). Milrinone (0.1-1 mg/kg) has positive inotropic effects, increasing cardiac contractile force in anesthetized dogs with a concomitant increase in heart rate but not blood pressure. It also increases contractile force in models of propranolol- and verapamil-induced heart failure in anesthetized dogs when administered at an initial dose of 30 µg/kg followed by a continuous 3 µg/kg per minute infusion. Milrinone has vasodilatory effects as well, decreasing mean aortic pressure and increasing venous compliance in anesthetized dogs when administered at an initial dose of 10 µg/kg followed by a continuous 1.7-2.4 µg/kg per minute infusion. Formulations containing milrinone have been used in the treatment of heart failure.