LtaS-IN-1 (compound 1771) 是一种高效的小分子脂磷壁酸 (LTA) 抑制剂，可抑制耐多药 (MDR) 大肠杆菌中脂磷壁酸 (LTA) 的合成，并可改变细胞壁的形态。LtaS-IN-1 单独使用抑制肠球菌的生长的 MIC 值范围从 0.5 μg/mL 到 64 μg/mL。LtaS-IN-1 与抗生素联合使用几乎可以完全抑制耐多药的大肠杆菌生长。
货号:ajcx17002
CAS:877950-01-1
分子式:C24H17N3O5
分子量：427.41
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].

[1]. Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents. 2017 Mar;49(3):355-363.