BLM-IN-1 (compound 29) 是有效的、布鲁姆综合征蛋白 (BLM) 的抑制剂，对BLM的KD 值为1.81 μM，IC50 值为0.95 μM。可诱导DNA损伤反应，癌细胞的凋亡和增殖抑制。
货号:ajcx39562
CAS:2056014-40-3
分子式:C28H35FN4O
分子量：462.6
溶解度:DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells[1].

[1]. Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162.