SMS2-IN-1 是一种高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂，其 IC50 为 6.5 nM，Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性是 SMS1 (IC50 为 1000 nM) 的 150 倍。
货号:ajcx39438
CAS:2098890-15-2
分子式:C34H37F6N3O5
分子量：681.67
溶解度:DMSO : 27.78 mg/mL (40.75 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1].

AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2[1].

[1]. Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293.