SHIP2-IN-1 是一种有效的 SHIP2 抑制剂，IC50 值为 2 µM。SHIP2-IN-1 可使 GSK3β 的 Ser9 位点磷酸化，抑制 GSK3β 的活化。SHIP2-IN-1 可用于阿尔滋海默症的研究。
货号:ajcx39326
CAS:2252247-80-4
分子式:C17H13Cl2FN4O
分子量：379.22
溶解度:DMSO : 100 mg/mL (263.70 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer's disease[1].

SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].

[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.