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Usmarapride free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Usmarapride free base图片
规格:98%
分子量:383.49
包装与价格:
包装价格(元)
5mg询价
10mg询价
25mg询价

Usmarapride (SUVN-D4010) free base 是一种有效的、具有选择性、口服活性和可透过血脑屏障的 5-HT4 受体部分激动剂 (EC50=nM)。Usmarapride (SUVN-D4010) free base 可用于阿尔茨海默病相关认知缺陷的研究。
货号:ajcx38046
CAS:1428862-32-1
分子式:C21H29N5O2
分子量:383.49
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT)[1].Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia[1].Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index[1].Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats[1].

[1]. Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64(15):10641-10665.

 
 
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