Azido-PEG8-acid 是一种不可降解 (non-cleavable) 的含 8 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG8-acid 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
货号:ajcx36452
CAS:1214319-92-2
分子式:C19H37N3O10
分子量：467.51
溶解度:DMSO : 100 mg/mL (213.90 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Tan M, et al. Peptide-targeted Nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging. Biomacromolecules. 2010 Mar 8;11(3):754-61.