Lenalidomide-C4-NH2hydrochloride是一种基于Lenalidomide的，可募集CRBN蛋白的Cereblon配体。Lenalidomide-C4-NH2hydrochloride可通过linker与靶蛋白配体连接，形成PROTAC分子，如文献中的Compound24，其对RS4;11和MOLM-13细胞的IC50值分别为0.98nM和13.7nM。
货号:ajcx30906
CAS:N/A
分子式:C17H22ClN3O3
分子量：351.83
溶解度:DMSO: 130 mg/mL (369.50 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.