Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
货号:ajcx27938
CAS:498577-46-1
分子式:C30H26F2N2O3
分子量：500.55
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID:21362619