TL 12-186 是一种依赖于大脑的多激酶 PROTAC 降解剂。多激酶包括 CDK、BTK、FLT3、Aurora 激酶、TEC、ULK、ITK 等。 TL 12-186 抑制 CDK2/cyclin A (IC50\u003d73 nM) 和 CDK9/cyclin T1 (IC50\u003d55 nM)。
货号:ajcx27650
CAS:2250025-88-6
分子式:C44H51ClN10O9S
分子量：931.46
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC® comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide . Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 is also available. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID:29129717