Ceefourin 1 是一种有效且高度选择性的多药耐药蛋白 4 (MRP4) 抑制剂。 Ceefourin 1 抑制多种 MRP4 底物的转运，但对 MRP4 的选择性高于其他 ABC 转运蛋白。 Ceefourin 1 是一种苯并噻唑，主要用作高危神经母细胞瘤的化学增敏剂。
货号:ajcx27280
CAS:315702-40-0
分子式:C11H10N4S3
分子量：294.42
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 .

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID:24973542