RA 839 是 Keap1 的非共价小分子结合剂，Kd 约为 6 μM，是 Nrf2 信号传导的选择性激活剂。
货号:ajcx27194
CAS:1832713-02-6
分子式:C25H28N2O4S
分子量：452.57
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID:26459563