An N-nitrosamine
货号:ajcx26636
CAS:614-00-6
分子式:C7H8N2O
分子量：136.2
溶解度:Chloroform: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Nitroso-N-methylaniline is an N-nitrosamine.¹It induces the formation of esophageal, pharyngeal, and tongue tumors in rats when administered at a concentration of 200 mg/L in the drinking water or 15 mg/mlviaoral gavage.²N-Nitroso-N-methylaniline is toxic to rats with LD₅₀values of 336 and 225 mg/kg for male and female rats, respectively. It reduces survival of hamsters but only induces a low incidence of tumors in this species when administered at a dose of 5 mg/week for a total dose of 1.8 mmol.¹

1.Lijinsky, W., and Kovatch, R.M.Comparative carcinogenesis by nitrosomethylalkylamines in Syrian hamstersCancer Res.48(23)6648-6652(1988) 2.Goodall, C.M., Lijinsky, W., Tomatis, L., et al.Toxicity and oncogenicity of nitrosomethylaniline and nitrosomethylcyclohexylamineToxicol. Appl. Pharmacol.17(2)426-432(1970)