A non-essential amino acid
货号:ajcx25552
CAS:5794-13-8
分子式:C4H8N2O3·H2O
分子量：150.1
溶解度:Methanol: slightly soluble,PBS (pH 7.2): slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Asparagine is a non-essential amino acid.¹It is formed from L-aspartic acid and L-glutamine by asparagine synthetase (ASNS), and it is deamidated by L-asparaginase to produce L-aspartic acid and ammonia.^2,3L-Asparagine (0.3 mM) reversesASNSsiRNA knockdown-induced decreases in proliferation in a panel of six human cancer cell lines, indicating that both exogenous and endogenous L-asparagine promote proliferation of these cells.⁴Formulations containing L-asparagine have been used as dietary supplements.

1.Chiu, M.I., Taurino, G., Bianchi, M.G., et al.Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemiaFront. Oncol.91480(2020) 2.Zhu, W., Radadiya, A., Bisson, C., et al.High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivityCommun. Biol.2345(2019) 3.Covini, D., Tardito, S., Bussolati, O., et al.Expanding targets for a metabolic therapy of cancer: L-AsparaginaseRecent Pat. Anticancer Drug Discov.7(1)4-13(2012) 4.Pathria, G., Lee, J.S., Hasnis, E., et al.Translational reprogramming marks adaptation to asparagine restriction in cancerNat. Cell Biol.21(12)1590-1603(2019)