An internal standard for the quantification of sumatriptan
货号:ajcx23540
CAS:1397195-80-0
分子式:C14H15D6N3O2S.1/2C4H6O4
分子量：360.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sumatriptan-d₆is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT_1Band 5-HT_1D(IC₅₀s = 9.3 and 7.3 nM, respectively).¹It also binds to the 5-HT_1Freceptor (IC₅₀= 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC₅₀= 89.9 nM), an effect that can be reduced by the 5-HT_1B/1Dreceptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.²Formulations containing sumatriptan have been used in the treatment of migraine headache.

1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)