An insecticide and acaricide
货号:ajcx23502
CAS:283594-90-1
分子式:C23H30O4
分子量：370.5
溶解度:Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesisviainhibition of acetyl-CoA carboxylase.^1,2It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC₅₀s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).³It induces toxicity in whitefly (T. vaporariorum) nymphs (LC₅₀= 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC₅₀= 0.16 mg/kg), and second instar larvae ofS. littoralislab and field strains (LC₅₀s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).^1,2,3Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pestsH. armigera,O. nubilalis, andP. xylostella, respectively, and induces 100% mortality inM. separatawhen used at a dose of 100 mg/kg.²It induces toxicity inD. magna(EC₅₀= >0.092 mg a.s./L) and the fish speciesO. mykissandL. macrochirus(LC₅₀s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD₅₀= >2,000 mg/kg).⁴Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC₅₀= 12.1 μM).⁵

1.Karatolos, N., Williamson, M.S., Denholm, I., et al.Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid replacement in its target enzyme acetyl-coenzyme A carboxylaseInsect Mol. Biol.21(3)327-334(2012) 2.Liu, Z., Lei, Q., Li, Y., et al.Design, synthesis, structure, and acaricidal/insecticidal activity of novel spirocyclic tetronic acid derivatives containing an oxalyl moietyJ. Agric. Food Chem.59(23)12543-12549(2011) 3.Ismail, S.M., and Morshedy, M.Evaluation of some environmentally safe cemicals against Spodoptera littoralisAlexandria Sci. Exch. J.30(1)121-127(2009) 4.Authority, E.F.S.Conclusion on the peer review of the pesticide risk assessment of the active substance spiromesifenEFSA J.10(10)2879(2012) 5.Chronopoulou, E.G., Papageorgiou, A.C., Markoglou, A., et al.Inhibition of human glutathione transferases by pesticides: Development of a simple analytical assay for the quantification of pesticides in waterJ. Mol. Catal. B: Enzymatic8143-51(2012)