An opioid peptide
货号:ajcx22230
CAS:N/A
分子式:C40H50N8O10.XC2H4O2
分子量：802.9
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dermorphin is an opioid peptide originally isolated from the skin of South American frogs (Ph. sauvagei).¹It binds to μ-opioid receptors (K_i= 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (K_i= 929 nM).In vivo, dermorphin (1.9 µmol/kg, i.p.) inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats.²It inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons. Dermorphin (10-120 pmol/animal, i.c.v.) delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats.

1.Usenko, A.B., Emel'yanova, T.G., and MIasoedov, N.F.Dermorphins are natural opioids with an unique primary structure that determines their biological specificityBiol. Bull. Russ. Acad. Sci.29154-164(2002) 2.Melchiorri, P., and Negri, L.The dermorphin peptide familyGen. Pharmacol.27(7)1099-1107(1996)