12(S)-HETE-d8 在 5、6、8、9、11、12、14 和 15 位含有 8 个氘原子。 12(S)-HETE-d8 旨在用作通过 GC 或 LC 质谱 (MS) 定量 12(S)-HETE 的内标。 12(S)-HETE-d8 是哺乳动物血小板的主要脂氧合酶产物。它在 0.1 μM 处增强肿瘤细胞与内皮细胞、纤连蛋白和内皮下基质的粘附。
货号:ajcx21076
CAS:84807-90-9
分子式:C20H24D8O3
分子量：328.5
溶解度:0.1 M Na2CO3: 2 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS pH 7.2: 0.8 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

12(S)-HETE-d₈contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. It is intended for use as an internal standard for the quantification of 12(S)-HETE by GC-or LC-mass spectrometry (MS). 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.¹It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.^2,3

1.Hamberg, M., and Samuelsson, B.Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human plateletsProc. Natl. Acad. Sci. U.S.A.71(9)3400-3404(1974) 2.Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4)1029-1037(1989) 3.Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5)413-429(1992)