SD 2590(hydrochloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	555

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价

An MMP inhibitor
货号:ajcx20758
CAS:226395-93-3
分子式:C22H25F3N2O7S • HCl
分子量：555
溶解度:DMSO: 100 mM,Water: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = <0.1, 28.7, 1.7, 0.18, and <0.1 nM, respectively).1 It is selective for these MMPs over MMP-1 and MMP-7 (IC50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals.

|1. Becker, D.P., Barta, T.E., Bedell, L.J., et al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J. Med. Chem. 53(18), 6653-6680 (2010).