m-PEG11-acid 是一种不可降解 (non-cleavable) 的含 11 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG11-acid 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
货号:ajcx38794
CAS:2280998-74-3
分子式:C24H48O13
分子量：544.63
溶解度:DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Protocol:

PEGs	Non-cleavable