MM41 是一种有效的人类端粒和基因启动子 DNA 四聚体稳定剂。 MM41 对 MIA PaCa-2 胰腺癌细胞有明显的抑制作用,IC50 值<10 nm。
货号:ajcx37912
CAS:1429028-96-5
分子式:C44H66N10O6
分子量:831.06
溶解度:DMSO : 33.33 mg/mL (40.11 mM; ultrasonic and adjust pH to 8 with HCl)
纯度:98%
存储:Store at -20°C
库存:
现货Background:
MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of<10 nM[1].
[1]. Marialuisa Micco, et al. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J Med Chem