HBC599 是一种非荧光 HBC 模拟物。HBC 在溶液中是非荧光的，但在与 Pepper RNA 适体形成紧密的络合物时会发出强烈的荧光。HBC-Pepper 复合物可用于观察活细胞中 RNA 的动态变化。
货号:ajcx35900
CAS:2530162-00-4
分子式:C21H17N3OS
分子量：359.44
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HBC599 is a HBC analog. HBC is nonfluorescent in solution, but emits strong fluorescence upon forming tight complex with Pepper RNA aptamer. HBC-Pepper complex can be used to visualize RNA dynamics in live cells[1].

Pepper can activate the fluorescence of HBC. Mammalian cells expressing Pepper exhibits robust greenyellowish fluorescence on incubation with 1 μM HBC[1].Peppers allow simple and robust imaging of diverse RNA species in live cells with minimal perturbation of the target RNA’s transcription, localization and translation[1].

[1]. Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019 Nov;37(11):1287-1293.