4’-Methoxychalcone 通过 PPARγ 活化调节脂肪细胞分化，并调节参与胰岛素敏感性的脂肪组织中各种脂肪因子的表达和分泌。
货号:ajcx34446
CAS:959-23-9
分子式:C16H14O2
分子量：238.28
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4’-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4’-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

4’-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1].4’-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1].4’-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1].

[1]. Han Y, et al. Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARγ activation and reverse effect on TNF-α in 3T3-L1 cells. Food Chem Toxicol. 2017 Aug;106(Pt A):17-24.