β-Aminopropionitrile 是一种特异的不可逆赖氨酰氧化酶 (LOX) 抑制剂。β-Aminopropionitrile 靶向 LOX 或 LOXL 同工酶的活性位点。
货号:ajcx32832
CAS:151-18-8
分子式:C3H6N2
分子量：70.09
溶解度:DMSO : 130 mg/mL (1854.76 mM)|H2O : 50 mg/mL (713.37 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].

β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro[2].

[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.
[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.