TP-TRFS是高度选择性的、首个硫氧还蛋白还原酶(TrxR)双光子荧光探针。
货号:ajcx31998
CAS:N/A
分子式:C16H15NO3S2
分子量：333.43
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)[1].

TP-TRFS (10 μM) exhibits weak fluorescence (φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h[1].

TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function[1].

[1]. Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb). 2020 Nov 12;56(90):14075-14078.