Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
货号:ajcx27554
CAS:901230-11-3
分子式:C21H27N5O3S
分子量：429.54
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.

Wang et al (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 121 204 PMID:28457974