Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
货号:ajcx27532
CAS:902146-11-6
分子式:C15H20F6N2O5
分子量：422.32
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID:15105298 |Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID:16821767