C26H45NO7S
货号:ajcx19632
CAS:32747-07-2
分子式:C26H45NO7S
分子量：515.7
溶解度:20mg/mL in ethanol, or DMSO, 30mg/mL in DMF
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .[1] THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.[2] It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.[3] THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.[4]

参考文献
[1]. Wahlstr?m, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[2]. Juste, C., Catala, I., Henry, R., et al. Influence of bile salt molecular species on cholesterol crystallization from supersaturated model biles. Biochim. Biophys. Acta. 1254(1), 89-97 (1995).
[3]. Scholmerich, J., Kitamura, S., Baumgartner, U., et al. Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liver. Res. Exp. Med. (Berl.) 190(2), 121-129 (1990).
[4]. Wang, X., Xie, G., Zhao, A., et al. Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosis. J. Proteome Res. 15(4), 1126-1134 (2016).