UNC6852是一种基于 PROTACT 技术的，选择性的 PRC2 降解剂，包含了一个 EED 配体和一个 VHL 配体，对 EED 作用的 IC50 值为 247 nM。
货号:ajcx16916
CAS:2688842-08-0
分子式:C43H48N10O6S
分子量：832.97
溶解度:DMSO: 100 mg/mL (120.05 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED[1].

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.