2,3-Dihydroxy-4-methoxyacetophenone 是一种来自圆锥花草的神经保护化合物。2,3-Dihydroxy-4-methoxyacetophenone 可以改善认知功能，具有用于阿尔茨海默氏病研究的潜力。
货号:ajcx37976
CAS:708-53-2
分子式:C9H10O4
分子量：182.17
溶解度:DMSO : 100 mg/mL (548.94 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research[1].

2,3-Dihydroxy-4-methoxyacetophenone protects HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50=10.94 μM). 2,3-Dihydroxy-4-methoxyacetophenone inhibits [Ca2+] accumulation in HT22 cells and has antioxidantive activity[1].

2,3-dihydroxy-4-methoxyacetophenone (50mg/kg; po) improves the impairment of spatial memory induced by scopolamine[1].

[1]. Jin Bae Weon, et al. The Ameliorating Effects of 2,3-dihydroxy-4-methoxyacetophenone on Scopolamine-Induced Memory Impairment in Mice and Its Neuroprotective Activity. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6732-6.