A peptide antibiotic
货号:ajcx22770
CAS:1374772-61-8
分子式:C69H66N18O13S5
分子量：1515.7
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.¹It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 µg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 µg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 µg/ml).²In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ofE. faecium-induced septicemia. It decreases the number of colony forming units (CFUs) in a mouse model of MRSA lung infection.

1.Martin, J., da S. Sousa, T., Crespo, G., et al.Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustrisMar. Drugs11(2)387-398(2013) 2.Mahajan, G., Thomas, B., Parab, R., et al.In vitro and in vivo activities of antibiotic PM181104Antimicrob. Agents Chemother.57(11)5315-5319(2013)