靶标：
ABCB7
产品别名：
ABC7； ASAT； Atm1p； EST140535； ABCB7； ATP binding cassette subfamily B member 7； ATP binding cassette subfamily B member 7； iron-sulfur clusters transporter ABCB7, mitochondrial； ABC transporter 7 protein； ATP-binding cassette sub-family B member 7, mitochondrial； ATP-binding cassette transporter 7； ATP-binding cassette, sub-family B (MDR/TAP), member 7； ATP结合盒转运蛋白B7(ABCB7)； ATP结合蛋白家族7；
背景信息：
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms hav
