靶标：
ACVR1
产品别名：
ACTRI； ACVR1A； ACVRLK2； ALK2； FOP； SKR1； TSRI； ACVR1； activin A receptor type 1； activin A receptor type 1； activin receptor type-1； TGF-B superfamily receptor type I； activin A receptor, type I； activin A receptor, type II-like kinase 2； activin receptor type I； activin receptor-like kinase 2； hydroxyalkyl-protein kinase； serine/threonine-protein kinase receptor R1； 激活素A受体Ⅰ(ACVR1)； 激活素受体1A；
背景信息：
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular
