靶标：
AK2
产品别名：
ADK2； AK2； adenylate kinase 2； adenylate kinase 2； adenylate kinase 2, mitochondrial； ATP-AMP transphosphorylase 2； ATP:AMP phosphotransferase； adenylate kinase isoenzyme 2, mitochondrial； adenylate monophosphate kinase； testis secretory sperm-binding protein Li 220n； 腺苷酸激酶2； 腺苷酸激酶2(AK2)；
背景信息：
Adenylate kinase 2 is an enzyme is encoded in humans by the AK2 gene. The AK2 protein is found in the intermembrane space of the mitochondrion. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
