靶标：
ALOX12
产品别名：
12-LOX； 12S-LOX； LOG12； ALOX12； arachidonate 12-lipoxygenase, 12S type； arachidonate 12-lipoxygenase, 12S type； polyunsaturated fatty acid lipoxygenase ALOX12； 12S-lipoxygenase； Arachidonate 12-lipoxygenase, 12S-type； arachidonate (12S)-lipoxygenase； arachidonate (15S)-lipoxygenase； arachidonate 15-lipoxygenase,15S-type； linoleate 13S-lipoxygenase； lipoxin synthase 12-LO； platelet 12-LOX； platelet-type 12-lipoxygenase； platelet-type lipoxygenase 12； 12脂氧合酶； 花生四烯酸-12-脂加氧酶(ALOX12)；
背景信息：
ALOX12, Arachidonate 12-lipoxygenase, is an enzyme that in humans is encoded by the ALOX12 gene. By fluorescence in situ hybridization, the ALOX12 gene is located in band 17p13.1. The gene consists of 14 exons with 13 introns and spans approximately 15 kb of DNAArachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. The major pathway of arachidonic acid metabolism in human platelets proceeds via a 12-lipoxygenase enzyme. Expression of the LOG12 gene was detected in human erythroleukemia cells, platelets, and human umbilical vein endothelial cells by reverse transcription-PCR analysis.
