靶标：
APLP2
产品别名：
APLP-2； APPH； APPL2； CDEBP； APLP2； amyloid beta precursor like protein 2； amyloid beta precursor like protein 2； amyloid beta precursor like protein 2； CDEI box-binding protein； amyloid beta (A4) precursor-like protein 2； amyloid precursor protein homolog HSD-2； sperm membrane protein YWK-II； testicular tissue protein Li 23； 淀粉样蛋白β前体样蛋白2； 淀粉样蛋白β前体样蛋白2(APLP2)；
背景信息：
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
