靶标：
ARHGDIB
产品别名：
D4； GDIA2； GDID4； LYGDI； Ly-GDI； RAP1GN1； RhoGDI2； ARHGDIB； Rho GDP dissociation inhibitor beta； Rho GDP dissociation inhibitor beta； rho GDP-dissociation inhibitor 2； Rho GDI 2； Rho GDP dissociation inhibitor (GDI) beta； rho-GDI beta； Rho GDP解离抑制因子β(ARHGDIb)； 肿瘤转移抑制基因GDIA2；
背景信息：
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
