靶标:
BMP3
产品别名:
BMP-3A; BMP3; bone morphogenetic protein 3; bone morphogenetic protein 3; bone morphogenetic protein 3; bone morphogenetic protein 3 (osteogenic); bone morphogenetic protein 3A; osteogenin; 骨形态发生蛋白3; 骨成型蛋白3(BMP3);
背景信息:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],