靶标：
BPGM
产品别名：
DPGM； ECYT8； BPGM； bisphosphoglycerate mutase； bisphosphoglycerate mutase； bisphosphoglycerate mutase； 2,3-bisphosphoglycerate mutase, erythrocyte； 2,3-bisphosphoglycerate synthase； 2,3-diphosphoglycerate mutase； BPG-dependent PGAM； erythrocyte 2,3-bisphosphoglycerate mutase； testis secretory sperm-binding protein Li 202a； 二磷酸甘油酸变位酶(BPGM)； 红细胞2,3 -二磷酸甘油酸合成酶；
背景信息：
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
