靶标:
CACNA1C
产品别名:
CACH2; CACN2; CACNL1A1; CCHL1A1; CaV1.2; LQT8; TS; TS. LQT8; CACNA1C; calcium voltage-gated channel subunit alpha1 C; calcium voltage-gated channel subunit alpha1 C; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; voltage-dependent L-type Ca2+ channel alpha 1 subunit; L-型电压依赖型钙通道α; L-型电压依赖钙离子通道α1C亚基(CACNa1C); L型钙通道蛋白;
背景信息:
calcium voltage-gated channel subunit alpha1 C(CACNA1C) Homo sapiens This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012],