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着丝粒蛋白B抗体
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

着丝粒蛋白B(CENPB)抗体
Anti-CENPB
靶标:

CENPB


产品别名:

CENPB; centromere protein B; centromere protein B; major centromere autoantigen B; CENP-B; centromere autoantigen B; centromere protein B, 80kDa; 着丝粒蛋白B; 着丝粒蛋白B(CENPB);


背景信息:
Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
 
 
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