靶标：
AKR1C4
产品别名：
3-alpha-HSD； C11； CDR； CHDR； DD-4； DD4； HAKRA； AKR1C4； aldo-keto reductase family 1 member C4； aldo-keto reductase family 1 member C4； aldo-keto reductase family 1 member C4； 3-alpha-HSD1； 3alpha-hydroxysteroid 3-dehydrogenase； chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4； dihydrodiol dehydrogenase isozyme DD4； type I 3-alpha-hydroxysteroid dehydrogenase； 羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ；
背景信息：
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008],
